https://github.com/gorhill/uBlock/issues/150 needs to be fixed here too

src/js/uritools.js

@@ -366,11 +366,18 @@ var domainCachePrune = function() {
     }
 };
 
+var domainCacheReset = function() {
+    domainCache = {};
+    domainCacheCount = 0;
+};
+
 var domainCache = {};
 var domainCacheCount = 0;
 var domainCacheCountLowWaterMark = 75;
 var domainCacheCountHighWaterMark = 100;
 
+psl.onChanged.addListener(domainCacheReset);
+
 /******************************************************************************/
 
 URI.domainFromURI = function(uri) {

src/lib/publicsuffixlist.js

@@ -33,6 +33,8 @@
 
 ;(function(root) {
 
+'use strict';
+
 /******************************************************************************/
 
 var exceptions = {};
@@ -45,6 +47,8 @@ var selfieMagic = 'iscjsfsaolnm';
 var cutoffLength = 256;
 var mustPunycode = /[^a-z0-9.-]/;
 
+var onChangedListeners = [];
+
 /******************************************************************************/
 
 // In the context of this code, a domain is defined as:
@@ -234,6 +238,8 @@ function parse(text, toAscii) {
     }
     crystallize(exceptions);
     crystallize(rules);
+
+    callListeners(onChangedListeners);
 }
 
 /******************************************************************************/
@@ -302,11 +308,47 @@ function fromSelfie(selfie) {
     }
     rules = selfie.rules;
     exceptions = selfie.exceptions;
+    callListeners(onChangedListeners);
     return true;
 }
 
 /******************************************************************************/
 
+var addListener = function(listeners, callback) {
+    if ( typeof callback !== 'function' ) {
+        return;
+    }
+    if ( listeners.indexOf(callback) === -1 ) {
+        listeners.push(callback);
+    }
+};
+
+var removeListener = function(listeners, callback) {
+    var pos = listeners.indexOf(callback);
+    if ( pos !== -1 ) {
+        listeners.splice(pos, 1);
+    }
+};
+
+var callListeners = function(listeners) {
+    for ( var i = 0; i < listeners.length; i++ ) {
+        listeners[i]();
+    }
+};
+
+/******************************************************************************/
+
+var onChanged = {
+    addListener: function(callback) {
+        addListener(onChangedListeners, callback);
+    },
+    removeListener: function(callback) {
+        removeListener(onChangedListeners, callback);
+    }
+};
+
+/******************************************************************************/
+
 // Public API
 
 root = root || window;
@@ -317,7 +359,8 @@ root.publicSuffixList = {
     'getDomain': getDomain,
     'getPublicSuffix': getPublicSuffix,
     'toSelfie': toSelfie,
-    'fromSelfie': fromSelfie
+    'fromSelfie': fromSelfie,
+    'onChanged': onChanged
 };
 
 /******************************************************************************/